Governments are under increasing pressure to meet the Social Development Goals (SDG) by 2030. Digital social innovation has been perceived as an important strategy to address several of the social and environmental needs of developing countries, especially Latin America. Digital social innovation results from the digitalization of resources, capabilities, processes, products, services, and business models with the goal of addressing a social or environmental need. Little is known about the factors that promote the success of these business initiatives in Latin America. In this paper, we analyzed 100 companies that developed and commercialized these initiatives and identified 4 general factors that might influence the success of these initiatives. Applying fsQCA and as preliminary results, we found that the prominence of the company, the type of technology used in the service or product offered, and funds raised are key factors to promote digital social innovation initiatives that are financially sustainable and socially scalable.