In a (post-)pandemic world, digital innovation has gained relevance as an important driver of digital economies. This paper combines systematic literature review and thematic analysis to isolate enablers of and barriers to digital innovation success. The review draws on an initial set of 421 papers, sourced from Google Scholar and the Web of Science databases, selected by title, topic, abstract and keywords. Out of the 421, 38 papers were selected. Unique and similar factors that emerged from the review have been isolated and discussed in more detail. By understanding the enablers and barriers, digital entrepreneurship stakeholders in the Global South can embrace best practices towards creation of an enabling environment that supports successful implementation of digital innovations. Particularly, this research has potential to influence favorable policy formulation and the targeting of funding to support technology innovators to stimulate digital innovations that power digital economies.