The Internet and other integration tools, such as software for supply chain management (SCM), as well as electronic interactions between business players in the product’s value chain, have transformed the economy. This transformation has been described by a variety of names, including innovation economy, knowledge economy, network economy, informational economy. The convergence and interaction between a new technological paradigm and a new organizational logic constitute the historic basis of informational economy. Thus, the present research aims to analyze the role of E-collaboration technologies in the design of virtual organizations. The methodology adopted for this research was case study, performed in two organizations from the manufacturing sector. The study investigated the main variables involved in the company’s process of organizing itself virtually, with direct reflections on its organizational design.