The presented study investigates the impact of Green information system (Green IS) practices on organizational performance benefits in the context of a small and medium-sized enterprise (SME). Three categories of Green IS practices, namely pollution prevention, product stewardship and sustainable development are taken into consideration. Furthermore, organizational benefits are considered to capture the extent to which SMEs achieve environmental and social performance. Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to analyse survey data collected from 156 managers of SMEs. The results indicate, that Green IS for pollution prevention and sustainable development have a significant impact on environmental and social performance, while product stewardship is not an effective source of perceived organizational benefits in neither of the proposed aspects. To achieve a higher level of organizational benefits arising from Green IS practices, more focus should be given to the strategic orientation of using Green IS in SMEs. From an academic perspective, the paper enhances the current knowledge in investigating the link between Green IS practices and organizational benefits, particularly in the SMEs perspective.