Efficiently managed information is a key resource in clinical practice. Electronic patient records (EPRs) are in focal point in managing patient-specific medication information. In this multi-method-study, we combine qualitative and quantitative data to investigate Finnish physicians’ perceptions of EPRs. Physicians consider EPRs important in their clinical practice and use them in managing patients’ medication information while addressing a considerable dissatisfaction with quality of the current EPRs. Altogether the findings highlight the need for improving the quality of the systems and increasing the physicians’ satisfaction to materialize the benefits from the EPRs