In this paper we present the e3alignment framework and approach, which we use to explore a wide range of inter-organizational alignment issues concerning the interaction between organizations in a value web, as seen from multiple perspectives, and with the aid of modeling techniques. The e3alignment approach focuses on interaction between actors, since “interaction” is one of the key success factors for a sustainable value web. Our ultimate goal is to create a sustainable value web, where various organizations cooperate to successfully meet a consumer need. To support our claims we conducted an industrial strength case study at the Dutch aviation sector.