While a variety of information technology (IT) acceptance and use models have been extensively examined and validated in numerous contexts, most studies have been conducted in western cultures, and thus not much is known about the probable moderating role of culture on the relationships between the constructs in those models. To fill this gap in the literature, we propose to empirically investigate the probable moderating roles of national cultural differences on the relationships between the constructs in the Unified Theory of Acceptance and Use of Technology (UTAUT): a model that consolidates the most prominent eight previous IT acceptance and use models. Hofstede’s five national cultural dimensions that provide a framework for national cultural differences are employed as the moderators. A self-administered survey questionnaire will be sent to healthcare practitioners in ten major healthcare organizations, five each from Taiwan and the U.S., to solicit their responses regarding their acceptance and use of Clinical Decision Support Systems (CDSSs). The findings from this proposed research are expected to generate both theoretical and practical implications.