This paper presents a case of a campus based online teaching experience. The case is based on a Management Information Systems course for large sections in two modalities: online and hybrid settings with 30 and 70 students respectively. The purpose of the project is to identify the challenges in teaching large online sections. The main results are that given the current technology, we can overcome the class size limitations for on-line courses; that according to active learning experiences, we can use active learning recommendations in online course design; that given technologies like Blackboard and Breeze, students‟ expectations and needs can be properly fulfilled with large sections; that given differences in course goals, only cognitive based courses can take advantages of online teaching; and that given the characteristics of a Management Information Systems course, it can be taught online. These results are important for researchers, professors, and university authorities.