Though hospital information systems have been extensively studied as a technology and there is now a growing body of literature in the area of infrastructure interdependencies, the dependencies of civil and built infrastructure on the health care information infrastructure (HII) is understudied. In particular, there is no study to our knowledge that addresses the issue of Hospital Information Infrastructure in the context of disasters. This study explores how an organization’s information systems infrastructure is affected by disasters and examines the relationship between organizational resilience and information infrastructure effectiveness by using conceptual model.