Global enterprises increasingly deploy Knowledge Management Systems (KMSs) to raise productivity and remain competitive. KMSs, by prescribing ways of capturing and disseminating information, mediate the learning processes in organizations. Because of this mediating effect, individuals from distinct national cultures may react differently to KMSs. This research examines how cultural characteristics (e.g., those identified by Hofstede, Trompenaars, and Hall and Hall) may be related to the individual use of KMSs for learning. The first phase of the study examines individual cultural characteristics and learning preferences (degree of structure and extent of direct social interactions). The second phase examines the relationships between cultural measures and actual KMS use.