In most European countries public health is stepping towards an economic crises. Extensive competition thus challenges healthcare organizations to redesign their business, to evaluate their product/services portfolios, and to develop new strategies. In this context, the paper examines the creation of competitive advantage through telemedicine-based value webs. Telemedicine has the potential to offer new distribution channels to healthcare services, and it enables creating new cooperation and business models. The focus of our paper is on how information technology and in particular telemedicine can create new, or may change traditional business models in healthcare.