The purpose of this paper is to explore the impact of Information Systems (IS) on the fundamental questions of life. This paper presents a few of the many issues that lie at the intersection of IS, philosophy, and spirituality. Such issues include the need to incorporate meaning and values in the foundation of IS; the evolution of IS from transaction processing systems to virtual community networks; the distinction between data, information, knowledge, and wisdom; and the evolving role of IS in a changing context. A Web site will be created to enable further discussion of these significant issues