Healthcare information systems encompass a wide range of issues from many disciplines including medicine, computer science, management science, statistics, biomedical engineering and numerous others. In the natural progression toward use of computers in healthcare, researchers in this multidisciplinary field are examining numerous issues ranging from examining the potential of artificial intelligence applications to application of total quality management principles to healthcare. This paper discusses various issues in an attempt toward development of a first cut framework/taxonomy of research themes and agendas for MIS researchers.