The use of information technology (IT) has increased in developing countries, especially during the COVID-19 pandemic era, since many have been forced to stay indoors to stop the spread of the virus. IT use means the acquisition and use of smart devices and Apps that make work and communication from home efficient. Women in developing countries who also have to work from home have challenges of acquiring IT. They must solely care for the family as it is the norm. This potentially increases burnout. This study, therefore, seeks to understand how women in developing countries appropriate IT for work-life balance during COVID-19. This study employs qualitative autoethnography methodology and theoretical lens of technology appropriation to recount how female academics appropriate IT in Ghana during the COVID-19 pandemic. We present an analysis and discussion of the empirical finding through the three levels of the technology appropriation process that support Work-Life balance.