Indirect use of hospital information systems (HIS), denoting the designated physicians’ indirect interaction with HIS through delegating HIT-related tasks to others, has become a popular phenomenon in hospitals. Indirect use frees physicians from busy work and helps them achieve improved productivity, however, agency theory and organization literature alert that the consequences of indirect use may departure from physicians’ expectation due to agency problems. To resolve such challenges, prior work places great emphasis on formal control and social control. Considering the nature of hospital setting, this study proposes that agent’s self-control could also be a prominent control mechanism. To obtain a comprehensive understanding, this study builds a research model to depict the impacts of the three control mechanisms and their interplays on indirect use performance. Proposed methodology and preliminary findings are also discussed in this study, which aims to provide insights about how to perform indirect use efficiently and effectively.