Inter-organizational knowledge networks have been considered vital for the knowledge economy, particularly for small and medium size enterprises in knowledge-based industries, since creating knowledge often happens within those networks. Hence an interesting question to explore is how do knowledge networks serve to contribute to knowledge creation? Beyond the role of network structure, which has dominated the knowledge network literature, our research highlights the need for the consideration of other factors like knowledge content. First by reviewing the literature, we propose a hypothesis that predicted positive association of content and knowledge creation. Then, focusing on patent co-authorship networks of the biotechnology industry in Victoria, this research used an explanatory multiple case study approach to test the formulated hypothesis. By introducing new emergent constructs, the results provide more insight on the positive association of knowledge content and knowledge creation. Based on the emergent constructs, rival hypotheses are also developed for further research.