In 1987, the United Nation’s Brundtland Commission on Environment and Development appealed for educational institutions to put the world onto the paths to sustainability. Since the 1980s, many universities have attempted to make crucial contributions to addressing the challenges of sustainability, at some level. Unfortunately, despite considerable activity, few universities have succeeded in realizing their potential to make significant contributions to environmental sustainability in research or education or as adopters of sustainable practices within their institutions. This paper aims to assist universities in achieving greater contributions to the challenges of sustainability by examining drivers, inhibitors, activities and outcomes in a longitudinal field study of sustainability initiatives at a single university over a period of 20 years. Insights include the key role for IS-enabled innovation and integrated roles for IS scholars.