The purpose of this paper is to enhance understanding of how the models of national culture have been used in Information Systems research. Using the top 10 ranking journals, as defined by the Association of Information Systems, we review and categorise 60 papers published over the past 15 years. The essential criterion for selection was that they applied different models of national culture. The findings show that the number of national culture models used in IS research has increased over the years and most of these studies were conducted using a survey. As expected, Hofstede’s dimensions of national culture have been used widely in IS research. It has also been found that models of national culture have been used for various purposes, namely management information systems, communication, knowledge management, project management, IT infrastructure, quality management systems, risk management, leadership, supply chain management and technology acceptance model. We note that in this era of globalisation the increased use of national culture to frame IS research is necessary to understand why IS initiatives may be successful in one country but not realised in another.