To survive in the increasingly competitive and complex world of business, a concept that has gained extensive popularity recently is business transformation, and Information Technology (IT) is said to be a strong candidate to enable such strategic endeavours. This paper is based on a research-in-progress and attempts to look at the potential of a specialized kind of IT called ‘Enterprise Systems’ (which has made waves in the industry and academia in recent times) in such transformation efforts. The contribution of the paper is that it synthesizes studies in the related areas of business transformations and the strategic potential of Information Systems (including Enterprise Systems). The paper also proposes a framework depicting how the adoption of Enterprise Systems can enable firms to strategically transform themselves. The intention is to follow this up with a detailed research project to validate the framework empirically.