This paper reports on the attitudes of 20 practitioners in South Australian General Practice towards adopting Health Informatics (HI) systems. HI systems are aimed at improving the overall quality and management of healthcare, but adoption of the technology may require a change in the General Practitioner’s (GP) approach to the way they perform their healthcare delivery role. This qualitative study found HI adoption was primarily influenced by the perceived potential for change in the professional’s value and role. While GPs were generally reluctant to consider technological innovation that was not perceived to demonstrate potential for improvement in patient health outcomes, increased exposure to HI systems positively influenced perceptions of both the importance and the certainty of potential implementation outcomes. It was concluded that GP attitudes could be characterised by four different perspectives of HI systems use in general practice medicine delivery.