Information systems (IS) professionals are being subjected to a plethora of occupational demands that can have a negative affect on their psychological well-being. The increasing incidence of absenteeism and high turnover rates are indications that IS professionals are experiencing high levels of job related stress. A factor that has contributed to businesses’ unawareness of the stress is the limited theoretical and empirical research that has examined the concept of stress among IS professionals. The job strain model (JSM) is one of the most widely applied theoretical models that have been used to underpin occupational stress research. In this paper, the predictive capabilities of the full JSM, which encompasses job demands, job control and social support, for IS professionals is examined. The results indicate that the JSM can be used to significantly predict employees’ psychological well-being in terms of worker health and job satisfaction among the IS professionals sampled in the United Kingdom (UK). The research demonstrated that social support had significant main effects on psychological well-being. Contrary to previous research, however, non-work related support was found to be more significant than work support in alleviating psychological strain.