Very limited trials have been conducted either industrially or academically in trying to uncover the potential of Internet of Things (IoT) in leveraging the societal problems in Africa. Based on the review of the current status of IoT implementation in Africa, we highlighted the potential opportunities to be taken into consideration by different stakeholders to leverage the living standards in the African nations. The study also identified some of the impending challenges that need to be addressed for a successful implementation of IoT solutions. The study proposes a framework that includes the relevant stakeholders, who need to cooperate harmoniously to alleviate the African countries’ challenges in areas such as agriculture and healthcare. This paper also proposes a multi-perspective research framework and aims to test it empirically to understand the views of IoT among users and practitioners in Africa.