The objective of this paper is to examine the EFQM Excellence Model as an enabler of E-procurement adoption and the effect on purchasing performance. The study utilized a cross-sectional telephone survey of a sample of Spanish manufacturing companies using multiple informants. A total of 200 firms responded making a total of 800 responses. Data was analyzed using structural equations modelling. The results indicate that the Business Excellence Enablers (Leadership, Strategy, People, Resources, and Processes) act as enablers of E-procurement and help to realize gains in purchasing performance.