Regional electronic marketplaces (REMs) are currently one of the measures adopted by some local governments and regional organizations to improve uptake of e-commerce by small and medium enterprises (SMEs). The rationale behind this move is to ensure SMEs do not fall on the wrong side of a digital divide. REMs are also viewed as a way to improve business efficiency and increase trade within the locality, expand into new markets and develop the region generally. However, while the development and management of REMs can be advised by a number of theoretical frameworks and models, there is no one definitive framework that can be used to comprehensively examine the factors that facilitate and inhibit the successful implementation of such e-marketplaces. This paper reviews the literature on e-marketplaces and IT/IS/ e-commerce adoption by SMEs and discusses how the constructs of existing theories and models can be used to examine REM success. It demonstrates how the constructs can be combined, refined and extended with insights from involvement in a REM in Western Australia and from content analysis of published case studies of e-marketplaces and emarketplace participation, to form an integrated theoretical framework upon which the assessment of REM success can be grounded.