We are witnessing significant investments by the healthcare industry globally in information technology (IT) to enhance patient outcomes, safety, efficiency, and financial performance. However, unlike other industries, the complexity of healthcare confounds the evaluation of the business value of these IT solutions and thus to date it has been difficult to clearly articulate the true business value of IT in healthcare contexts. This exploratory study addresses this problem by examining three clinical IT systems in the Australian healthcare context: a nursing documentation (ND) System, a computerized physician order entry (CPOE) solution, and an Incident Reporting System (IRS). The results indicate that these systems have the potential to provide better business value and have direct and indirect impacts on patient outcomes, efficiency, safety, and the overall performance at different levels, depending on a multiplicity of factors all of which need to be considered.