Calculating the process driven value of RFID investments is very difficult. From a company’s perspective it is important to understand the concrete contribution of an RFID system with regard to individual processes. The problem of profitability analyses in IS is that such technologies cannot be calculated as an economic standard investment. Hence, we propose a reference model as a generic knowledge base for referential RFID impacts. Our model supports the structuring and evaluation of RFID benefits along business processes. With this, we propose indicators for the derivation of an RFID cause-and-effect chain. The allocation of RFID effects to processes within the reference framework helps in identifying the right logistic unit levels for RFID transponder investments.