While a significant level of research has been dedicated to developing computer anti-virus software using analogies with the human immune system, few development frameworks for the creation of the anti-virus software have been exposed to the broader community of interest. This paper discusses the biological theory related to the human body’s immune system and how immune systems might be innovatively mimicked in the development of security systems and software. The paper outlines the Bio-mimicry framework that can be used for scoping the development and features of the security systems and software, including the population of the framework segments. Some commercial security products that are undergoing evolutionary development and current research and development activities are used to augment the development framework and explicate its use in practice.