Information Technology (IT) usage is increasingly focused on interaction processes rather than data storage and transaction. This change fundamentally transforms work practices, and these practices in interplay with human agents and technology in turn affect the boundaries for scope of action. In this paper, we explore nurses’ use of Electronic Patient Records (EPRs) for sensemaking and other elucidating processes that support, co- create, and mediate collective learning and social practice, thereby contributing to individual and organizational knowledge.