In Australia the concept of e-Research has been developing rapidly over the last three years. e-Research effort is currently focused on infrastructure building and on tools development. In the short term this will have pay- offs in large data-intensive research domains and in opportunistic niche uses of the technology. But the sustainable value of e-Research will only be realized by the broad-scale use of systems that employ that infrastructure. The Information Systems discipline has the approaches and techniques needed to make e- Research effective.